The US Oncology Network in The News

Unique, collaborative real-world research consortium will study up to 12,000 NSCLC patients in the community setting over five years

MYLUNG to deepen understanding of barriers and address challenges to improve care for lung cancer patients, including those with targetable mutations

The MYLUNG consortium – or “Molecularly Informed Lung Cancer Treatment in a Community Cancer Network: A Pragmatic Consortium” – will observe up to 12,000 community-based, metastatic NSCLC patients over a five-year period in one of the first broad, collaborative, research endeavors in lung cancer. In particular, MYLUNG aims to deepen understanding of molecular testing barriers to improve care for lung cancer patients, including those with mutations who may benefit from receiving precision medicine, the practice of leveraging targeted therapies across the continuum of care, as well as expand the opportunity for patients to participate in clinical trials.

“Many patients are not receiving the molecular testing they need to initiate targeted therapy early in their cancer care journey due to long timeframes, lack of coverage or another factor. This testing is critical to determine the patient’s cancer at a molecular level, so oncologists can create a more targeted and precise treatment plan,” said Robert L. Coleman, MD, FACOG, FACS, chief scientific officer, US Oncology Research. “In order to fulfill the promise of precision medicine for NSCLC patients, we need a fuller understanding of the barriers, challenges, risks and opportunities around molecularly guided therapies. MYLUNG will draw insights from these datasets that can lead to better therapy for patients in a timelier manner.”

Lung cancer treatment is becoming increasingly personalized to include targeted therapies into earlier stages of disease. To support this, MYLUNG provides the framework to conduct research studies that will help define best practices for providers, as well as provide insights for life sciences companies seeking to quickly deliver potentially life-saving treatments to the patients who need them.

The MYLUNG consortium brings together several McKesson-supported organizations focused on transforming and enhancing the cancer care experience including The US Oncology Network, US Oncology Research, and Ontada^TM – McKesson’s new oncology technology and insights business – along with life sciences companies and patient advocacy groups. MYLUNG life sciences members currently include Amgen, Eli Lilly and Company and Mirati Therapeutics. Healthcare provider members include Illinois Cancer Specialists, Maryland Oncology Hematology, Minnesota Oncology, New York Oncology Hematology, Oncology Hematology Care, Rocky Mountain Cancer Centers, Southern Cancer Center, Virginia Cancer Specialists, Virginia Oncology Associates and Willamette Valley Cancer Institute and Research Center. Additional collaborators are expected to join throughout the next few months.

“McKesson has always served at the center of care delivery, which has provided a unique perspective on the complexities of cancer care and the growing needs among providers and life sciences companies,” said Kirk Kaminsky, president, McKesson U.S. Pharmaceutical. “MYLUNG highlights our ability to integrate a continuous virtual cycle with feedback loops between the US Oncology Research and Ontada research teams and The US Oncology Network sites of care to quickly integrate best practices across The Network, while adaptively responding to the constantly changing landscape of oncology discovery for both diagnostics and treatment.”

MYLUNG will consist of three protocols over a five-year period:

• Protocol 1 retrospectively reviews real-world data from Ontada’s iKnowMed^SM electronic health records (EHRs) of about 3,500 patients treated by providers in The US Oncology Network to understand baseline data on molecular testing across practices and identify historical barriers to testing and precision medicine in community practice.
• Protocol 2, enrolling about 1,000 patients from approximately 10 practices, will monitor the real-world patient journey from presentation through their first line of cancer therapy, focusing on how diagnostic biomarker information is obtained, utilized and operationalized in decision-making. Patients are currently being enrolled into Protocol 2.

The real-world research model is uniquely suited to take lung cancer care to the next level by providing a window into the actual provider and patient experience. “We created Ontada to help providers, patients and life sciences companies navigate a cancer care world that is growing more complex every day as new precision medicines come to market,” said Derek Rago, interim president, Ontada. “MYLUNG will gather real-world data with Ontada’s technology solutions and develop novel insights through its real-world analytics capabilities so that all stakeholders can make informed decisions that are actionable at the point-of-need.”

MYLUNG is poised to support meaningful progress and innovation in care delivery and potentially touch and improve thousands of lives. Makenzi Evangelist, MD, physician lead for the pragmatic study and oncologist with New York Oncology Hematology (NYOH), a practice in The Network, said, “During the study and after, we hope that the interventions and our understanding of NSCLC improve, and we see increased testing and appropriate use of targeted therapies – all of which we hope will improve cancer care and patient outcomes.”

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About McKesson Corporation
McKesson Corporation is a global leader in healthcare supply chain management solutions, retail pharmacy, community oncology and specialty care, and healthcare information solutions. McKesson partners with pharmaceutical manufacturers, providers, pharmacies, governments and other organizations in healthcare to help provide the right medicines, medical products and healthcare services to the right patients at the right time, safely and cost-effectively. United by our ICARE shared principles, our employees work every day to innovate and deliver opportunities that make our customers and partners more successful – all for the better health of patients. McKesson has been named the “Most Admired Company” in the healthcare wholesaler category by FORTUNE, a “Best Place to Work” by the Human Rights Campaign Foundation, and a top military-friendly company by Military Friendly. For more information, visit www.mckesson.com.

About Ontada
Ontada is an oncology technology and insights business dedicated to transforming the fight against cancer. Part of McKesson Corporation, Ontada was founded on the core belief that precise insights – delivered exactly at the point of need – can save more patients’ lives. We connect the full patient journey by combining technologies used by The US Oncology Network and other community oncology providers with real-world data and research relied on by all top 15 global life sciences companies. Our work helps accelerate innovation and power the future of cancer care. For more information, visit ontada.com or follow @OntadaOncology.

About US Oncology Research
US Oncology Research draws from a network of experienced investigators and dedicated clinical staff who specialize in oncology clinical trials. US Oncology Research serves approximately 60 research sites and more than 165 locations, managing about 400 active trials at any given time. For the past 20 years, physicians in the research network have enrolled more than 82,000 patients in over 1,600 trials and have played a role in more than 100 FDA-approved cancer therapies. US Oncology Research is supported by McKesson Corporation.

About The US Oncology Network
Every day, The US Oncology Network (The Network) helps more than 1,380 independent physicians deliver value-based, integrated care to patients — close to home. Through The Network, these independent doctors come together to form a community of shared expertise and resources dedicated to advancing local cancer care and to delivering better patient outcomes. The Network provides practices with access to coordinated resources, best business practices, and the experience, infrastructure and support of McKesson Corporation. This collaboration allows the providers in The Network to focus on the health of their patients, while McKesson focuses on the health of their practices. The Network is committed to the success of independent practices, everywhere.

Media Contacts
The US Oncology Network, US Oncology Research
Claire Crye, Public Relations
281.825.9927 claire.crye@mckesson.com

Ontada
Annabelle Baxter, External Communications
469.233.3400 annabelle.baxter@mckesson.com